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M9480520.TXT
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1994-08-20
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Document 0520
DOCN M9480520
TI Hepatitis C virus (HCV) viremia in human immunodeficiency
virus-seronegative and -seropositive patients with indeterminate HCV
recombinant immunoblot assay.
DT 9410
AU Marcellin P; Martinot-Peignoux M; Elias A; Branger M; Courtois F; Level
R; Erlinger S; Benhamou JP; Service d'Hepatologie, INSERM U24, Hopital
Beaujon, Clichy,; France.
SO J Infect Dis. 1994 Aug;170(2):433-5. Unique Identifier : AIDSLINE
MED/94308614
AB Positivity of recombinant immunoblot assay (RIBA) for detection of
antibodies to hepatitis C virus (anti-HCV) is usually associated with
HCV viremia. The significance of an indeterminate RIBA result, defined
by reactivity to only one HCV antigen, is unclear. Whether anti-human
immunodeficiency virus (HIV)-negative or -positive subjects with an
indeterminate RIBA have HCV viremia detectable by polymerase chain
reaction was investigated. An indeterminate RIBA was found in 48 (15%)
of 318 anti-HIV-negative and 38 (23%) of 167 anti-HIV-positive subjects
(P < .05). Clinical stage was IV-C-1 or IV-C-2 in 82% of those
anti-HIV-positive. HCV viremia was found more frequently in
anti-HIV-positive (89%) than in anti-HIV-negative subjects (50%) with an
indeterminate RIBA (P < .05). These results suggest an impaired anti-HCV
response associated with HIV infection.
DE Alanine Aminotransferase/BLOOD Antigens, Viral/IMMUNOLOGY
Enzyme-Linked Immunosorbent Assay Hepatitis Antibodies/BLOOD Hepatitis
C/*COMPLICATIONS Hepatitis C Viruses/GENETICS/IMMUNOLOGY Human *HIV
Seronegativity HIV Seropositivity/*COMPLICATIONS Immunoblotting
Polymerase Chain Reaction Recombinant Proteins/IMMUNOLOGY RNA,
Viral/BLOOD Support, Non-U.S. Gov't Viremia/*COMPLICATIONS JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).